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Miconazole How long does it take for day treatment to absorb inside you? Posted by Jpenny answers. So I took the monistat day treatment for a yeast infection. I wasn't really having any symptoms, other than the discharge, so I decided to just use the one day insert the big round capsul ish looking thing ..The leaflet in the package states that it can take up to seven days to get rid of the yeast infection. I believe each day is better than the previous day. I think the clumply discharge is the Monistat slowly breaking down and leaving the "area'. For me, after about days there was no longer the clumpy discharge..MONISTAT is prescription strength, cures right at the source of the infection, and is the doctor recommended over the counter OTC brand. While MONISTAT products offer the most time convenient yeast infection treatment course, most women do not experience relief from the infection in just one day..Monistat tioconazole You may have some improvement on symptoms on day of Monistat if none by day tell your physician in .Download Full Image